The Src family of protein tyrosine kinases, which includes Src, Lyn, Fyn, Yes, Lck, Blk, and Hck, are important in the regulation of growth and differentiation of eukaryotic cells. Src activity is regulated by tyrosine phosphorylation at two sites, but with opposing effects. While phosphorylation at Tyr416 in the activation loop of the kinase domain upregulates enzyme activity, phosphorylation at Tyr530 in the carboxy‑terminal tail by Csk renders the enzyme less active.
The kinase Fyn plays a role in T‑cell receptor signaling and also helps in memory formation and adhesion mediated signaling. Lymphocyte specific kinase Lck is essential in the differentiation and activation of T‑cells. Hematopoietic Lyn kinase, also phosphorylated by Csk, is involved in the regulation of B‑cell function, migration and development. The ubiquitously expressed kinase Yes acts downstream of several different cell surface receptors, including G‑protein‑coupled receptors, and is involved in the regulation of angiogenesis, the cell cycle and cell adhesion.
| Target | Catalog# | Product Name | Reactivity | Application |
|---|---|---|---|---|
| Phospho‑Src (Tyr530) | AMRe02877 | Phospho‑Src (Tyr530) Rabbit Monoclonal Antibody | Rat | WB,IP |
| Phospho‑Src (Y529) | AMRe06016 | Phospho‑Src (Y529) (9B14) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,ICC/IF,FC |
| Src | AMRe21265 | Src Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,IF,ELISA |
| Phospho‑c‑Src (Tyr529) | APRab04514 | Phospho‑c‑Src (Tyr529) Rabbit Polyclonal Antibody | Human,Mouse,Rat,Monkey | WB,IHC,ICC/IF,ELISA |
| Phospho‑c‑Src (Tyr419) | APRab04512 | Phospho‑c‑Src (Tyr419) Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,ELISA |
| Phospho‑c‑Src (Tyr216) | APRab04511 | Phospho‑c‑Src (Tyr216) Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,ELISA |
| Phospho‑c‑Src (Ser75) | APRab04510 | Phospho‑c‑Src (Ser75) Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,ELISA |
| CSK | AMM80904 | CSK Mouse Monoclonal Antibody | Human,Mouse,Monkey,Rat | WB,ICC,ELISA,FC |
| Phospho‑CSK (Ser364) | APRab00939 | Phospho‑CSK (Ser364) Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB,ELISA |
| Phospho‑Csk (Ser364) | APRab04508 | Phospho‑Csk (Ser364) Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,ELISA |
| FYN | AMM03462 | FYN (4B8) Mouse Monoclonal Antibody | Human,Monkey,Rat,Mouse | WB,ICC/IF |
| Phospho‑Fyn (Tyr530) | APRab04712 | Phospho‑Fyn (Tyr530) Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,ELISA |
| Lck | AMRe02208 | Lck Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,IF,IP,ELISA |
| Phospho‑Lck BP‑1 (Tyr397) | APRab04948 | Phospho‑Lck BP‑1 (Tyr397) Rabbit Polyclonal Antibody | Human,Rat,Mouse | WB,IHC |
| Phospho‑Lck (Tyr505) | APRab04946 | Phospho‑Lck (Tyr505) Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,ELISA |
| Phospho‑Lck (Tyr393) | APRab04945 | Phospho‑Lck (Tyr393) Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB,ICC/IF,ELISA |
| Phospho‑Lck (Tyr192) | APRab04944 | Phospho‑Lck (Tyr192) Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB,ELISA |
| Phospho‑Lck (Ser540) | APRab04943 | Phospho‑Lck (Ser540) Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB,ELISA |
| Lyn | AMRe13509 | Lyn (9T13) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB |
| Phospho‑Lyn (Y396) | AMRe05938 | Phospho‑Lyn (Y396) (18J18) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IP |
| Phospho‑Lyn (Tyr508) | APRab04963 | Phospho‑Lyn (Tyr508) Rabbit Polyclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,ELISA |
| Yes1 | AMRe21073 | Yes1 Rabbit Monoclonal Antibody | Human | WB,IHC,ICC/IF,ELISA,IP |
Related Products
Super-sensitive ECL chemiluminescent reagent
References
- Src, Fyn and Yes play differential roles in VEGF‑mediated endothelial cell events. Werdich XQ, et al. Angiogenesis. 2005. [PMID: 16400523]
- The SH4‑Unique‑SH3‑SH2 domains dictate specificity in signaling that differentiate c‑Yes from c‑Src. Summy JM, et al. J Cell Sci. 2003. [PMID: 12734402]
- Novel roles for Lyn in B cell migration and lipopolysaccharide responsiveness revealed using anti‑double‑stranded DNA Ig transgenic mice. Seo S, et al. J Immunol. 2001. [PMID: 11238611]
- Activation of Fyn tyrosine kinase in the mouse dorsal hippocampus is essential for contextual fear conditioning. Isosaka T, et al. Eur J Neurosci. 2008.
- Function of the Src‑family kinases, Lck and Fyn, in T‑cell development and activation. Palacios EH, et al. Oncogene. 2004. [PMID: 15489916]
- A tail of two src's: mutatis mutandis. Hunter T. Cell. 1987. [PMID: 3030562]
- Cellular functions regulated by Src family kinases. Thomas SM, et al. Annu Rev Cell Dev Biol. 1997. [PMID: 9442882]
- Regulation of Src Family Kinases during Colorectal Cancer Development and Its Clinical Implications. Jin W. Cancers (Basel). 2020. [PMID: 32456226]
