Senescence Associated Secretory Phenotype (SASP) Antibody

Senescence is characterized by stable stress-induced proliferative arrest and resistance to mitogenic stimuli, as well as the secretion of proteins such as cytokines, growth factors and proteases. These secreted proteins comprise the senescence-associated secretory phenotype (SASP). Senescent cells are thought to accumulate as an organism ages, and contribute to age-related diseases, including cancer, through promotion of inflammation and disruption of normal cellular function. The composition of the SASP varies, and SASP components can be either beneficial or deleterious in human disease, depending on the context.

Senescence Associated Secretory Phenotype (SASP) Antibody Sampler Kit provides a collection of antibodies to various SASP components, including TNF-alpha, interleukin-6 (IL-6), the multifunctional cytokine IL-1beta, the chemokines CXCL10, RANTES/CCL5 and MCP-1, the matrix metalloprotease MMP3, and the serine-protease inhibitor PAI-1.

Interaction between the generation of the senescence-associated secretory phenotype (SASP), immunosenescence, and cancer progression.

Relevant Antibodies

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Voisey  Voisey is a technical support specialist at EnkiLife, proficient in immunology and cell biology. She is committed to providing customers with professional and efficient technical support. Additionally, she  is involved in research on customers' fields of study and designs highly cost-effective solutions for them.